EVALUATION OF THE EFFECTIVENESS OF THE USE OF (PYRIDIN-4-YL)OXY SUBSTITUTED IMIDAZO[2,1-b][1,3]THIAZINES AS GROWTH INHIBITORS OF CUCUMIS SATIVUS

Abstract

In this work, the rust-inhibiting effect of new pyridine-substituted imidazo[2,1-b][1,3]thiazines was investigated. Model objects 6-[(pyridin-4-yl)oxy]-2,3-diphenyl-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 3a and 3-[ (pyridin-4-yl)oxy]-3,4-dihydro-2H-benzo[4,5]imidazo[2,1-b][1,3]thiazines 3b-d were synthesized by the interaction of 3-hydroxyimidazo[2,1-b][1,3]thiazines with 4-fluoropyridines. The obtained compounds were studied to identify the peculiarities of the physiological development of seedlings of the dicot plant Cucumis sativus. According to the results of the conducted experiment, it was established that the course of physiological processes in the plant organism has a multifaceted nature. The inhibitory effect depends on the structure of the compounds, the concentration of the solutions and the method of their application. It was shown that the synthesized (4-pyridinyloxy)imidazo[2,1-b][1,3]thiazines have a rather strong and stable inhibitory effect in concentrations of 0.1–0.001%. Depending on the intensity and nature of the manifestation of the inhibitory effect, the studied compounds can be placed in a series of increasing inhibitory effect: 3c<3d<3b<3a. Seed soaking in 0.01–0.0001% solutions for all compounds showed the same result with a strong inhibitory effect that caused complete embryonic death of the seeds. The investigated compounds are characterized by a certain period of intense inhibitory effect on the plant organism, therefore they are promising for studying them as components of "pre-emergence" herbicides.