GROWTH INHIBITING ACTIVITY OF (2-PYRIDINYLOXY)-SUBSTITUTED (BENZO) IMIDAZO [2,1-b][1,3] THIAZINES
DOI:
https://doi.org/10.32782/pcsd-2021-4-8Keywords:
6-[(pyridin-2-yl)oxy]-6,7-dihydro-5H-(benzo)imidazo[2,1-b][1,3]thiazines, 6-[(3,4-dihydro-2H-(benzo) imidazo[2,1-b][1,3]thiazin-3-yl)oxy] nicotino(isonicotino)nitriles, inhibiting activity, depressing effectAbstract
The work is devoted to the study of the growth regulating action of new compounds of imidazothiazine type, 6-[(pyridine- 2-yl)oxy]-6,7-dihydro-5H- (benzo)imidazo[2,1-b][1,3]thiazines and 6-[(3,4-dihydro-2H-(benzo)imidazo[2,1-b] [1,3]thiazine-3-yl)oxy]nicotino(isonicotino)nitriles. The synthesized compounds with a predetermined structure were investigated to identify the features of the physiological development of Cucumis sativus dicotyledon seedlings. According to the results of the experiment, it was established that the course of physiological processes in the plant organism is diverse. The ambiguity of inhibitory influence depends on the structure of the compound, the concentration of solutions and the method of application. It is shown that the result of soaking seeds in 0.1% concentration of working solutions of the investigated compounds is a highly pronounced inhibitory action that causes complete embryonic death of seeds. Whereas the use of solutions of test compounds at concentrations of 0.01 - 0.0001% shows both increasing and decreaing depressing effect. Thus, characterizing the intensity and nature of the inhibitory effects of the compounds and structures for the significance of this effect, the compounds 3a, 3f, 3i containing a trifluoromethyl substituted pyridine fragment exhibit episodic suppressing effect with sharply pronounced intervals. Compounds 3b, 3c, 3g, 3h, 3j with a cyano-containing pyridinyl nucleus exhibit moderately episodic suppressing effect which intensity does not reach critical values (the death of the plant organism) but is characterized by a certain interval of enhancing inhibitory effects. Finally, compounds 3d, 3e containing dichloro- and chlorotrifluoromethyl substituted pyridinyl fragments exhibit evenly expressed depressing effect wherein the inhibitory effect is uniformly distributed throughout the concentration spectrum.
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