SCREENING OF POTENTIAL CUCUMIS SATIVUS GROWTH INHIBITORS AMONG (IMIDAZO[2,1-b][1,3]-THIAZIN-6-YL)- 1,2,3-TRIAZOLE-5-CARBOXYLATE DERIVATIVES
DOI:
https://doi.org/10.32782/pcsd-2023-4-1Keywords:
alkyl 1-[(benzo)imidazo[2,1-b][1,3]thiazin-6-yl]-1H-1,2,3-triazole-5-carboxylates, 1-(2,3 -diphenyl-6,7- dihydro-5H-imidazo[2,1-b][1,3]thiazin-6-yl)-1H-1,2,3-triazole-5-carboxylic acid, growth regulating effect, suppressive effect, inhibitory activityAbstract
The work is devoted to the study of 6-azido-2,3-diphenyl-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine and 3-azido- 3,4-dihydro-2H-benz[4,5]imidazo[2,1-b][1,3]thiazine with acetylene carboxylates of the corresponding alkyl 1-[(benzo) imidazo[2,1-b][1,3]thiazin-6-yl]-1H-1,2,3-triazole-5-carboxylates and their hydrolysis product – 1-(2,3-diphenyl-6,7- dihydro-5H-imidazo[2,1-b][1,3]thiazine-6-yl)-1H-1,2,3-triazole-5-carboxylic acid on the growth-regulating activity, evaluating the influence of different concentrations of these substances and their structure on the features of the early growth and development of the plant organism Cucumis sativus at the stages of seed germination and seedling formation. According to the results of the conducted experiment, it was established that the course of physiological processes in the plant organism has a multifaceted nature. The same result is characteristic only when Cucumis sativus seeds are soaked in 0.01–0.001% solutions, where all compounds showed a strong inhibitory effect, which caused complete embryonic death of the seeds. In general, 1-(2,3-diphenyl-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-6-yl)-1H-1,2,3- triazole-5-carboxylic acid 4a has the highest inhibitory effect, the inhibitory effect of which is characterized by a decrease in seedling mass and length by 52.5 and 70.4%, respectively, compared to the control. Analyzing the structure of the studied compounds, it was established that Me, Et, t-Bu substituents in the carboxyl group help to weaken the inhibitory effect of (imidazo[2,1-b][1,3]-thiazin-6-yl)-1,2,3-triazolo-5-carboxylates, and the presence of two phenyl groups in the imidazole fragment increases the inhibitory effect on the growth and development of Cucumis sativus seedlings.
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