GROWTH INHIBITING ACTIVITY OF 2-(2-OXOINDOLINE-3-YLIDENE) SUBSTITUTED 5,6-DIHYDROIMIDAZO[2,1-b]-THIAZOLONES AND 6,7-DIHYDROTHIAZOLO[3,2-a]PYRIMIDINONES
DOI:
https://doi.org/10.32782/pcsd-2025-1-2Keywords:
2-(2-oxoindoline-3-ylidene)-5,6-dihydroimidazo[2,1-b]thiazol-3(2H)-ones, 2-(2-oxoindoline-3-ylidene)- 6,7-dihydro-2H-thiazolo[3,2-a]pyrimidin-3(5H)-ones, inhibitory activity, suppressive effect, growth stimulantsAbstract
The work is devoted to the study of the growth-regulatory action of new hydrogenated compounds of the imidazothiazole type – 2-(2-oxoindoline-3-ylidene)-5,6-dihydroimidazo[2,1-b]thiazol-3(2H)-ones and of the thiazolopyrimidine type – 2-(2-oxoindoline-3-ylidene)-6,7-dihydro-2H-thiazolo[3,2-a]pyrimidin-3(5H)-ones. The synthesized compounds with a predetermined structure were investigated to identify the features of the physiological development of seedlings of the dicotyledonous plant Cucumis sativus. According to the experiment results, it was established that the course of physiological processes in the plant organism is diverse. The ambiguity of the inhibitory effect depends on the concentration of solutions of the studied compounds and their structure. It was shown that when using a 0.1 % solution, in no case was the transition of cucumber seeds (Cucumis sativus) from dormancy to the beginning of active life recorded, and the use of compounds in increased doses was accompanied by a high inhibitory effect of the studied compounds, which caused the complete death of the plant organism, as confirmed by the rotting of the seeds. On the other hand, when using solutions of the tested compounds in concentrations of 0.01–0.0001 %, a decreasing inhibitory effect occurs. The most favorable for the growth and development of the plant organism at the early stages of organogenesis were 0.0001 % concentration of working solutions. Given the results obtained, further study of compounds 4a–c, 5a–c is appropriate in the context of their potential use as herbicides for controlling dicotyledonous weeds. Meanwhile, for compound 4g, a more detailed study of its biological activity with an emphasis on its possible use as a plant growth promoter is a promising direction.
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